DLC #23 - Resident Evil 5 Desperate Escape

Desperate Escape is hard. It completely ramps up the difficulty from the previous Lost in Nightmares DLC, despite having a similar trophy structure. Completing the episode on both Professional difficulty and with an S-Rank make a return, but carrying out both tasks are harder in this episode.                                                                                                                                                    
Enemies are plentiful and there's a killer final sequence right at the end which can make or break your chances of achieving that S-Rank trophy.                                                                                             
Prepare yourself for multiple playthroughs, because reaching that S-Rank and beating the episode on Professional will be a stern test that will no doubt need practise to perfect.                                    
Aside the S-Rank trophy, which is technically missable if you don't achieve an S-Rank at the end, there is another missable trophy;                                                                                                                         



Shoot the Messenger
Defeat 3 Agitator Majini in one playthrough of 'Desperate Escape.'




It's missable in the sense that, 3 Alligator Manjini may not spawn throughout the episode. There a 3 crux points where you're meant to see them, but theories on why they may not appear seem to vary. They're the guys in the below picture, but that's all I can really give you, so check the subforum out for more.                                                                                                                                          
Regardless, considering everything, this is a tough list, and I would certainly consider doing it on co-op for best results. If you get all trophies on offer here, consider it as a big success!

Like a woman out of your league, he might not show up.