DLC #10, 11, 12, 13 + 14 - Broken Steel, Operation Anchorage, The Pitt, Point Lookout and Mothership Zeta

Take on some episodic Fallout DLC

As far as I'm concerned, the less said about the Fallout 3 DLC, the better. The trophies are so easy to earn, but are made unnecessarily difficult by a plague of technical issues, from crashes, to glitches, to freezes, to framerate issues....Practically all the trophies are quest-line related, It just becomes a matter of stumbling through one broken piece of DLC to the next as you progress the quest-line and slowly unlock the trophies.
                                                             
There are a few collection based trophies in some of the DLC packs (Such as finding 100 Steel Ignots in The Pitt, Discovering every location in Point Lookout and Collecting all audio files in Motership Zeta), which will only prolong the agony as you hunt them down and fight through the game breaking problems.                   
                                        
It's also important to note that the Broken Steel (How appropriately named....) pack increases the level cap to 30, and has 3 karma related trophies, so make sure you perform the usual save game and reload trick in order to unlock all 3 easily.   
                                              
Unless you're a rabid completionist, avoid like the plague, it's just a good job the GOTY edition can be picked up so cheaply, especially so given the fact the DLC packs as a stand alone product are actually quite expensive.