As far as the trophies go, this is just essentially a series of challenges to slog through that see you slaughtering practically everything in the wasteland through unusual means, with 3 trophies tied to completing 9 different challenges of increasing difficulty.
The other 2 trophies, "Curious and Relics" and "Master of the Arsenal" require 10,000 points worth of damage with Gun Runner's Arsenal weapons, and unique Mojave weapons, both are which are provided by vendors as part of the DLC. These will flow naturally if you make sure you complete all the challenges with these types of weapons, speaking of which;
Some of the challenges in certain tiers just simply aren't worth the time and effort, and there are definitely easier alternatives (Why would you go through the hassle of killing 20 animals with the FatMan when you can just cripple 5 right arms with a shotgun, which takes no longer than 5 minutes?).
It's also worth nothing that, if you've already hit the end game (Given the fact this is the 5th DLC package, then chances are, you have) then some of the challenges become somewhat locked out, given the fact they require you to injure/kill certain story-related characters who may already be dead, meaning the only remedy to this issue is to play through the entire game again, which you're hardly likely to want to do.
Some of the three star challenges have an air of toughness about them, and despite the freedom of choice, you'll still feel like you're stuck between a rock and a hard place, since most of them involve tackling the Mojave's most dangerous enemies/characters.
Despite that, and assuming you accumulate the two, 10,000 damage related trophies along the way, you'll probably beat the package in around 6 hours or so. I tackled the challenges I felt were the easiest for every tier. They're listed below;
One Star Challenges :
- Benefit or Hazard
- The same could be said of all Religious weapons
- Ne, Ne, Ne, Ne...
Two Star Challenges :
- Dyin' ain't much of a Living
- Nyah! See?
- White Line Nightmare
Three Star Challenges :
- Against All Tyrants
- Armed For Bear
- Man-Machine Interface